Pathology of US porcine epidemic diarrhea virus strain PC21A in gnotobiotic pigs

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To understand the progression of porcine epidemic diarrhea virus infection, we inoculated gnotobiotic pigs with a newly emerged US strain, PC21A, of the virus. At 24–48 hours postinoculation, the pigs exhibited severe diarrhea and vomiting, fecal shedding, viremia, and severe atrophic enteritis. These findings confirm that strain PC21A is highly enteropathogenic. A highly contagious coronavirus that causes porcine epidemic diarrhea (PED) was first reported in the United States in May 2013 inIowa. Since then, the virus—porcine epidemic diarrhea virus (PEDV)—has spread rapidly nationwide. PEDV (family Coronaviridae, genus Alphacoronavirus) was previously reported only in Europe and Asia. The first US outbreaks caused a high number of deaths among suckling pigs and, as a consequence, substantial economic losses. Results of PEDV pathogenesis studies using the prototype European PEDV strain, CV777, were reported in the 1980s. Strain CV777 infections caused intestinal villous atrophy with substantially reduced ratios of villous height to crypt depth (VH:CD). Pathogenic features of CV777 are similar to those observed for Asian PEDV strains that circulated in the 1990s. To understand the progression of PEDV infection, we studied the pathogenesis of the newly emerged US strain, PC21A. Emerging Infectious Diseases

April 15, 2014  Original web page at Emerging Infectious Diseases


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