New Parvovirus in child with unexplained diarrhea, Tunisia

A divergent parvovirus genome was the only eukaryotic viral sequence detected in feces of a Tunisian child with unexplained diarrhea. Tusavirus 1 shared 44% and 39% identity with the nonstructural protein 1 and viral protein 1, respectively, of the closest genome, Kilham rat parvovirus, indicating presence of a new human viral species in the Protoparvovirus genus.

Parvoviruses are small icosahedral viruses with linear single-stranded DNA genomes of ≈5 kb that are associated with a wide spectrum of illnesses in humans and animals. The subfamily Parvovirinae, which infects vertebrates, is currently classified into 8 genera, 5 of which contain human parvoviruses (Dependoparvovirus, Erythroparvovirus, Bocaparvovirus, Tetraparvovirus, and Protoparvovirus). In 2012, bufaviruses 1 and 2 were sequenced from the feces of children with diarrhea from Burkina Faso and a child with nonpolio acute flaccid paralysis from Tunisia and classified as founding members of the primate protoparvovirus 1 species. Bufavirus DNA also was detected in diarrheal samples from adults in Finland and Holland and a child from Bhutan. A related protoparvovirus was recently found in feces and serum from rhesus monkeys with simian AIDS in primate research centers .

Read more:  Emerging Infectious Diseases  Original web page at Emerging Infectious Diseases