Prevalence of hepatitis E virus infection in pigs at the time of slaughter, United Kingdom, 2013

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Since 2010, reports of infection with hepatitis E virus (HEV) have increased in England and Wales. Despite mounting evidence regarding the zoonotic potential of porcine HEV, there are limited data on its prevalence in pigs in the United Kingdom. We investigated antibody prevalence, active infection, and virus variation in serum and cecal content samples from 629 pigs at slaughter. Prevalence of antibodies to HEV was 92.8% (584/629), and HEV RNA was detected in 15% of cecal contents (93/629), 3% of plasma samples (22/629), and 2% of both (14/629). However, although HEV is prevalent in pigs in the United Kingdom and viremic pigs are entering the food chain, most (22/23) viral sequences clustered separately from the dominant type seen in humans. Thus, pigs raised in the United Kingdom are unlikely to be the main source of human HEV infections in the United Kingdom. Further research is needed to identify the source of these infections.

Hepatitis E virus (HEV) that infects humans is composed of 4 genotypes (G1–4), each with a different geographic distribution and host range. Although G1 and G2 infect humans only, G3 and G4 infect humans and animals. HEV G3 and G4 are distributed worldwide, with G3 most commonly infecting both humans and pigs in Europe. From the observed incidence of acute HEV infection in blood donors, it is clear that HEV G3 infection in humans in England is far more common than previously thought. Realistic estimates are >100,000 infections annually.

Public Health England instituted enhanced surveillance of HEV infections in England and Wales in 2003 and identified a recent and marked increase in the number of patients seeking treatment for HEV infections. In 2013, a total of 691 cases were identified, of which 477 (69%) were considered indigenous (occurring in persons who had not traveled outside England and Wales). Sequencing of strains from these acutely infected persons has identified an emergent phylogenetic cluster of HEV G3 infection in humans, which is likely to represent a zoonosis acquired through the consumption of undercooked meat (B. Said, pers. comm.).

In an early study in the United Kingdom of porcine samples archived during 1991–2001, antibodies to HEV were detected in 85.5% of 256 samples tested. More recent studies across Europe indicate that many pig herds show evidence of HEV G3 infection. A transient viremia in pigs is associated with dissemination of HEV into muscle and other tissues. A recent UK study found HEV RNA in 6 of 63 pork sausages tested, of which 5 were in a single batch of 11, and a case−control study in England and Wales showed that human consumption of processed pork products is associated with an increased risk of acquiring HEV. It has long been considered plausible that the persistence of viremia in infected pigs up to the time of slaughter could provide a potential vehicle for zoonotic transmission to humans. We conducted surveillance of pigs at slaughter to investigate the epizoology of HEV in the United Kingdom and the extent of infection at the time pigs enter the food chain.

http://wwwnc.cdc.gov/eid/ Emerging Infectious Diseases

http://wwwnc.cdc.gov/eid/article/21/8/14-1995_article Original web page at Emerging Infectious Diseases

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