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More fat, less protein improves canine olfactory abilities

From sniffing out bombs and weapons to uncovering criminal evidence, dogs can help save lives and keep the peace. Now, researchers have uncovered how to improve dogs’ smelling skills through diet, by cutting protein and adding fats. Such a diet, say the researchers, appears to help dogs return to lower body temperatures after exercise, which reduces panting and, thereby, improves sniffing. The findings could change how detection dogs are fed and boost their detection abilities, says Joseph Wakshlag, associate professor of clinical studies and chief of nutrition at Cornell’s College of Veterinary Medicine. Wakshlag, who collaborated with researchers at Auburn University, is presenting the findings at the Companion Animal Nutrition Summit in Atlanta, held March 22-24. The study, funded with a $1 million grant from the U.S. Department of Justice, also found that detection dogs are more reliable detectors than previously thought. The study is the first to be conducted in the world’s only detection dog research facility designed in conjunction with a military dog trainer. The Alabama facility, which provides expert detection dogs to police and military forces, flushes out fumes between tests, ensuring a fresh field each time.

“Previous studies from other facilities, which lack this feature, had suggested detection dogs signaling for suspect substances are about 70 percent accurate,” said Wakshlag. “The lower numbers may have been due to study design flaws which our new study overcame. Dogs tested in the new facility signaled with 90 percent and above accuracy. We also found we can push detection performance even further with the right kind of food.” Bucking conventional thinking, the group found that less protein and more fat in the dogs’ diet helped trained dogs perform better in exercise and detection tests. During an 18-month period, they rotated 17 trained dogs through three diets Wakshlag selected: a high-end performance diet, regular adult dog food, and regular adult dog food diluted with corn oil. Measuring how different diets affected each dog, they found that dogs eating the normal diet enhanced with corn oil returned to normal body temperatures most quickly after exercise and were better able to detect smokeless powder, ammonia nitrate and TNT. “Corn oil has lots of polyunsaturated fats, similar to what you’d find in a lot of nuts and common grocery store seed oils,” said Wakshlag. “Past data from elsewhere suggest that these polyunsaturated fats might enhance the sense of smell, and it looks like that may be true for detection dogs. It could be that fat somehow improves nose-signaling structures or reduces body temperature or both. But lowering protein also played a part in improving olfaction.”

Wakshlag designed the high-performance and corn-oil diets to have the same amount of energy from fat (57 percent). But the corn oil diet had less protein: 18 percent compared with 27 percent in the regular and high-performance diets. “If you’re a dog, digesting protein raises body temperature, so the longer your body temperature is up, the longer you keep panting, and the harder it is to smell well,” said Wakshlag. “Our study shifts the paradigm of what ‘high-performance’ diet can mean for dogs. It depends on what you want your dog to do. A sled dog or greyhound may need more protein to keep going. But detection dogs tend to exercise in shorter bursts and need to recover quickly and smell well. For that, less protein and more fat could help.”

Science Daily
April 16, 2013

Original web page at Science Daily

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Feeding corn germ to pigs does not affect growth performance

Inclusion of corn germ in swine diets can reduce diet costs, depending on the local cost of corn germ and other ingredients. Recent research conducted at the University of Illinois indicates that corn germ can be included at up to 30 percent in diets fed to growing pigs. “In previous research, we had seen that pigs do very well on diets containing 10 percent corn germ, so we wanted to investigate if higher inclusion rates can be used,” said Hans Stein, professor of animal sciences at Illinois. The corn germ used in this study came from the ethanol, or dry grind, industry, and contained 16 to 18 percent fat. This product is different from the corn germ produced from the wet milling industry, which contains 30 to 40 percent fat. Stein’s team tested diets containing 0 percent, 10 percent, 20 percent, and 30 percent corn germ. They tested each inclusion level of corn germ in diets containing 30 percent distillers dried grains with solubles (DDGS) as well as in diets containing no DDGS. They found no difference in growth performance, carcass composition, muscle quality, or backfat quality as increasing amounts of corn germ were added to the diets, regardless of the inclusion level of DDGS.

“The results of this work demonstrate that pig growth rate will not be changed by the inclusion of up to 30 percent corn germ in the diets, and feed conversion rate will not be changed,” Stein said. All diets contained the same amounts of energy, standardized ileal digestible indispensable amino acids, and digestible phosphorus. Fat content was not held constant across diets; the diets containing more corn germ also contained more fat. As a result, the bellies of pigs fed diets with no DDGS were softer as corn germ levels increased. “Producers may have to reduce the inclusion rate during the final three to four weeks before slaughter,” Stein concluded. There was no effect on belly firmness in pigs fed diets containing DDGS. Stein said that research on whether reducing the inclusion rate of corn germ in late-finishing diets would ameliorate the negative effects on belly quality might be warranted. The study, “Up to 30 percent corn germ may be included in diets fed to growing-finishing pigs without affecting pig growth performance, carcass composition, or pork fat quality,” was published in the Journal of Animal Science.

Science Daily
April 16, 2013

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What do American bullfrogs eat when they’re away from home? Practically everything

American bullfrogs are native to eastern North America but have been transported by people to many other parts of the globe, and other parts of North America, where they have readily established populations and become an invasive alien menace to native ecosystems. In the largest study of its kind to date, the stomach contents of over 5,000 invasive alien American bullfrogs from 60 lakes and ponds on southern Vancouver Island were examined to identify the native and exotic animals that they had preyed upon. The study was published in the open access journal NeoBiota. Over 15 classes of animals were reported from a total of 18,814 identifiable prey remains, including terrestrial and aquatic insects, spiders, crayfish, fish, frogs, salamanders, newts, snakes, lizards, turtles, birds, and small mammals. The study examined the stomach contents of adults and juveniles of all size-classes, but excluded tadpoles. These results show that bullfrogs will attack and consume virtually any organism that is within reach and can be swallowed, including their own species.

Previous studies on bullfrog diet have examined relatively small numbers of stomachs from a comparatively small number of lakes and ponds. Our results reinforce the general consensus that there is good reason for concern about the ecological harm that uncontrolled populations of American bullfrogs might have, or are having, on populations of native species. For decades, bullfrogs have been transported and released around the world by prospective frog-farmers, pet owners, game managers, recreational fishermen, biological supply houses; and even by entrants in frog jumping contests. They adapt readily to a variety of habitats from the tropics to temperate zones and once established, their numbers grow fast with each adult female producing about 20,000 or more eggs per year. For these reasons, American bullfrogs are internationally recognized as one of the 100 worst invasive alien species in the world.

Science Daily
April 2, 2013

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Cows fed flaxseed produce more nutritious dairy products

Dairy cows that are fed flaxseed produce more nutritious milk, according to a new study by Oregon State University. Their milk contained more omega-3 fatty acids and less saturated fat, the study found. Diets high in saturated fat can increase cholesterol and cause heart disease, while those rich in omega-3 and other polyunsaturated fatty acids may reduce the risk of heart disease, studies have shown. Traditional cattle feed mixtures of corn, grains, alfalfa hay and grass silage result in dairy products with low concentrations of omega-3 and other polyunsaturated fats, according to Gerd Bobe, the lead scientist on the study, which has been published online in the Journal of Dairy Science. Ten pregnant cows at OSU’s dairy were fed different amounts of flaxseed — up to seven percent of their daily diet. Researchers attempted to pinpoint the amount of flaxseed that would maximize the amount of omega-3 in milk and dairy products without negatively affecting their production and texture. “We were looking for a sweet spot,” said Bobe, an expert in human and animal nutrition. “Too much of a good thing can be bad, especially when trying to maintain consistency with dairy products.”

Collaborators in OSU’s food science and technology department assisted in turning milk into butter and fresh cheese, which were then tested for texture and nutritional composition. The study found that feeding cows up to six pounds of extruded flaxseed improved the fat profile without negatively affecting the production and texture of the milk and other dairy products. Extrusion presses raw ground flaxseed into pellets with heat. At six pounds per day, saturated fatty acids in whole milk fat dropped 18 percent, poly-unsaturated fatty acids increased 82 percent, and omega-3 levels rose 70 percent compared to feeding no flaxseed. Similar improvements were observed in butter and cheese. Still, saturated fat accounted for more than half of the fatty acids in the dairy products while the increase in polyunsaturated fats compromised no more than nearly nine percent of the total. Researchers also noted that the refrigerated butter was softer and less adhesive thanks to fewer saturated fatty acids. Also, the cows produced the same amount of milk while eating flaxseed. Although flaxseed costs more than traditional cattle feeds, Bobe hopes that it still could be an affordable feed supplement for cows because products enriched with omega-3 can sell for a premium at the grocery store. “Many consumers already show a willingness to pay extra for value-added foods, like omega-3 enriched milk,” he said. One thing is for sure, he said: Dairy farmers will have no trouble convincing cows to eat flaxseed. “They loved it. They ate it like candy,” he said.

Science Daily
February 19, 2013

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Drought in the Horn of Africa delays migrating birds

The catastrophic drought last year in the Horn of Africa affected millions of people but also caused the extremely late arrival into northern Europe of several migratory songbird species, a study published December 6 in Science shows. Details of the migration route was revealed by data collected from small backpacks fitted on birds showing that the delay resulted from an extended stay in the Horn of Africa. The extensive 2011 drought in the Horn of Africa had significant consequences for European songbirds such as thrush nightingale and red-backed shrike. These birds visit northern Europe every spring to mate and take advantage of ample summer food resources. However, their spring migrating route from southern Africa to northern latitudes passes directly through the Horn of Africa, where the birds stop to feed and refuel for the next stage of their migration. “Our research was able to couple the birds’ delayed arrival in Europe with that stopover in the Horn of Africa. Here they stayed about a week longer in 2011 than in the years before and after 2011. Because of the drought, the birds would have needed longer to feed and gain energy for their onward travel, causing delayed arrival and breeding in Europe. This supports our theory that migrating animals in general are dependent on a series of areas to reach their destination,” says Associate Professor Anders Tøttrup from the Center for Macroecology, Evolution and Climate at the University of Copenhagen.

The late spring arrival of European songbirds such as thrush nightingale and red-backed shrike perplexed researchers and bird watchers in 2011. This mystery was even greater considering these songbirds’ tendency to arrive progressively earlier over the last 50 years as climate change has made its impact. By placing small data loggers on the backs of several birds in the autumn before their migration to Africa, and retrieving them in the spring when the birds returned to Europe, the scientists were able to trace the migration route and stopover sites. These data revealed a delay in the particular stopover in the Horn of Africa. Additionally, it was noted that other migrating birds not passing through the Horn of Africa arrived in Europe at the expected time. “We have reconstructed 26 migration routes based on data from the small ‘data backpacks’ weighing just 1 gram. This new technology provides us with a detailed picture of the birds’ migration and stopovers. It is brand-new territory to be able to track animals this small over such great distances,” says Associate Professor Kasper Thorup from the Center for Macroecology, Evolution and Climate at the University of Copenhagen. The birds’ late arrival in 2011 also meant a similarly late breeding year. “There are no signs of implications on the birds’ breeding success and thereby the size of the population. But it is possible that we haven’t yet seen the full effect of the delayed year,” concludes Anders Tøttrup. The research was carried out in collaboration with Lund University in Sweden.

Science Daily
January 8, 2013

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Dogs’ natural feeding intake is high in fat

An international team of researchers has shed new light on the natural feeding behavior of domestic dogs and demonstrated that they will naturally seek a daily dietary intake that is high in fat. An international team of researchers has shed new light on the natural feeding behaviour of domestic dogs and demonstrated that they will naturally seek a daily dietary intake that is high in fat. The study also showed that some dogs will overeat if given excess food, reinforcing the importance of responsible feeding to help ensure dogs maintain a healthy body weight. The research involved adult dogs representing five diverse breeds: the papillon, miniature schnauzer, cocker spaniel, Labrador retriever and St. Bernard. In a series of dietary studies, the dogs were offered combinations of wet or dry foods with varying levels of protein, fat and carbohydrate. The dietary nutrient balance selected by the different breeds was then assessed and compared. The results showed that, when given the choice, dogs consistently regulated their macronutrient intake, i.e. their intake of protein, fat and carbohydrate. Specifically, the dogs selected a macronutrient profile equating to approximately 63% of their daily calorie intake from fat, 30% from protein and 7% from carbohydrate. The findings also showed that some dogs consumed more than twice as many calories as required when offered excess food.

“The finding that domestic dogs will naturally seek a dietary intake that is high in fat and that they will readily overeat if given the opportunity probably reflects the feeding behaviour of their wild ancestors,” said lead study author, Adrian Hewson-Hughes from the Waltham Centre for Pet Nutrition. “In the wild, dogs and wolves often have irregular access to food and competition is fierce – leading them to try and maximise their calorie intake whenever possible.” “However, domestic dogs today have regular access to food and many lead relatively inactive lifestyles compared with their wild ancestors,” added Dr. Hewson-Hughes. “By demonstrating that dogs will overeat when offered excess food, this research also reinforces the importance of responsible feeding measures, such as portion control, for helping ensure dogs maintain a healthy body weight.”

EurekAlert! Medicine
November 13, 2012

Original web page at EurekAlert! Medicine

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Raw food not enough to feed big brains

Eating a raw food diet is a recipe for disaster if you’re trying to boost your species’ brainpower. That’s because humans would have to spend more than 9 hours a day eating to get enough energy from unprocessed raw food alone to support our large brains, according to a new study that calculates the energetic costs of growing a bigger brain or body in primates. But our ancestors managed to get enough energy to grow brains that have three times as many neurons as those in apes such as gorillas, chimpanzees, and orangutans. How did they do it? They got cooking, according to a study published online today in the Proceedings of the National Academy of Sciences. “If you eat only raw food, there are not enough hours in the day to get enough calories to build such a large brain,” says Suzana Herculano-Houzel, a neuroscientist at the Federal University of Rio de Janeiro in Brazil who is co-author of the report. “We can afford more neurons, thanks to cooking.” Humans have more brain neurons than any other primate—about 86 billion, on average, compared with about 33 billion neurons in gorillas and 28 billion in chimpanzees. While these extra neurons endow us with many benefits, they come at a price—our brains consume 20% of our body’s energy when resting, compared with 9% in other primates. So a long-standing riddle has been where did our ancestors get that extra energy to expand their minds as they evolved from animals with brains and bodies the size of chimpanzees?

One answer came in the late 1990s when Harvard University primatologist Richard Wrangham proposed that the brain began to expand rapidly 1.6 million to 1.8 million years ago in our ancestor, Homo erectus, because this early human learned how to roast meat and tuberous root vegetables over a fire. Cooking, Wrangham argued, effectively predigested the food, making it easier and more efficient for our guts to absorb calories more rapidly. Since then, he and his colleagues have shown in lab studies of rodents and pythons that these animals grow up bigger and faster when they eat cooked meat instead of raw meat—and that it takes less energy to digest cooked meat than raw meat. In a new test of this cooking hypothesis, Herculano-Houzel and her graduate student, Karina Fonseca-Azevedo, now a neuroscientist at the National Institute of Translational Neuroscience in São Paulo, Brazil, decided to see if a diet of raw food inherently put limits on how large a primate’s brain or body could grow. First, they counted the number of neurons in the brains of 13 species of primates (and more than 30 species of mammals).

The researchers found two things: One, that brain size is directly linked to the number of neurons in a brain; and two, that the number of neurons is directly correlated to the amount of energy (or calories) needed to feed a brain. After adjusting for body mass, they calculated how many hours per day it would take for various primates to eat enough calories of raw food to fuel their brains. They found that it would take 8.8 hours for gorillas; 7.8 hours for orangutans; 7.3 hours for chimps; and 9.3 hours for our species, H. sapiens. These numbers show that there is an upper limit on how much energy primates can get from an unprocessed raw diet, Herculano-Houzel says. An ape’s diet in the wild differs from a modern “raw food diet,” in which humans get sufficient calories from processing raw food in blenders and adding protein and other nutrients. In the wild, other apes can’t evolve bigger brains unless they reduce their body sizes because they can’t get past the limit of how many calories they can consume in 7 hours to 8 hours of feeding per day. But humans, she says, got around that limit by cooking. “The reason we have more neurons than any other animal alive is that cooking allowed this qualitative change—this step increase in brain size,” she says. “By cooking, we managed to circumvent the limitation of how much we can eat in a day.”

This study shows “that an ape could not achieve a brain as big as in recent humans while maintaining a typical ape diet,” Wrangham says. Paleoanthropologist Robert Martin of The Field Museum in Chicago, Illinois, agrees that the new paper does “provide the first evidence that metabolic limitations” from a raw food diet impose a limit on how big a primate’s brain—or body—can grow. “This could account for small brain sizes of great apes despite their large body sizes.” But “the jury is still out” on whether cooking was responsible for the first dramatic burst of brain growth in our lineage, in H. erectus, Martin says, or whether our ancestors began cooking over a fire later, when the brain went through a second major growth spurt about 600,000 years ago. Hearths show up in the archaeological record 800,000 years ago and the regular use of fire for cooking doesn’t become widespread until more recently. But to Herculano-Houzel’s mind, our brains would still be the size of an ape’s if H. erectus hadn’t played with fire: “Gorillas are stuck with this limitation of how much they can eat in a day; orangutans are stuck there; H. erectus would be stuck there if they had not invented cooking,” she says. “The more I think about it, the more I bow to my kitchen. It’s the reason we are here.”

ScienceNow
November 13, 2012

Original web page at ScienceNow

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Rat study sparks genetically modified food furore

Tumours developed more readily in rats fed genetically modified maize than in controls, recent research reports. Europe has never been particularly fond of genetically modified (GM) foods, but a startling research paper published last week looks set to harden public and political opposition even further, despite a torrent of scepticism from scientists about the work. The study, published in the peer-reviewed journal Food and Chemical Toxicology, looked for adverse health effects in rats fed NK603 maize (corn), developed by biotech company Monsanto to resist the herbicide glyphosate and approved for animal and human consumption in the European Union, United States and other countries. It reported that the rats developed higher levels of cancers, had larger cancerous tumours and died earlier than controls. The researchers have not conclusively identified a mechanism for the effect. The rats were monitored for two years (almost their whole life­span), making this the first long-term study of maize containing these specific genes. About a dozen long-term studies of different GM crops have failed to find such stark health effects. An earlier test of NK603 maize in rats in a 90-day feeding trial — the current regulatory norm — sponsored by Monsanto showed no adverse effects.

The explosion of media coverage about the findings has energized opponents of GM food, especially in Europe. French Prime Minister Jean-Marc Ayrault said that, if the results are confirmed, the government will press for a Europe-wide ban on the maize. The European Commission has instructed the independent European Food Safety Agency (EFSA) in Parma, Italy, to assess the study. Many scientists, however, have already questioned the study’s methodology and findings. They assert that the data presented in the paper do not readily allow the claims to be independently assessed, and they question the study’s experimental design and its statistical analysis of any differences between the treated groups and controls. Other scientists point out that the Sprague-Dawley strain of rats used in the experiments has been shown to be susceptible to developing tumours spontaneously, particularly as they grow older, making it difficult to interpret the results. Monsanto itself said that the study “does not meet minimum acceptable standards for this type of scientific research”.

The €3.2-million (US$4.1-million) study was led by Gilles-Eric Séralini, a molecular biologist at the University of Caen, France, in collaboration with the Paris-based Committee for Research and Independent Information on Genetic Engineering (CRIIGEN), whose scientific board he heads. CRIIGEN bills itself as an “independent non-profit organization of scientific counter-expertise to study GMOs, pesticides and impacts of pollutants on health and environment, and to develop non polluting alternatives”. The article’s publication coincides with the launch this week of a book by Séralini, Tous Cobayes? (All of Us Guinea-Pigs Now?), which tells the story of the research project and is accompanied by a film and a television documentary. In a written response to Nature’s questions, Séralini and Joël Spiroux de Vendômois, president of CRIIGEN and a co-author of the paper, say that they have been surprised by the “violence” and immediacy of scientists’ criticisms. They argue that most of the critics are not toxicologists, and suggest that some may have competing interests, including working to develop transgenic crops. They also point out some errors by critics, such as claims that graphs in the paper showing rat survival over time do not include data for the controls.

The authors concede that Sprague-Dawley rats may not be the best model for such long-term studies, but argue that the difference between the NK603-fed rats and controls is marked, and that many fewer control rats developed tumours in middle age. The 90-day trial of Monsanto’s NK603 maize used in its authorization also used Sprague-Dawley rats, they add. José Domingo, a toxicologist at Rovira i Virgili University in Reus, Spain, and a managing editor of Food and Chemical Toxicology, says that the study raised no red flags during peer review. Domingo, who last year authored a critical review of safety assessments of GM plants, has previously complained about the lack of independent feeding studies of GM foods. The controversy over the findings is likely to be settled only after detailed analysis of the paper and its data, and replication of the experiments. But Séralini says he won’t release his data until the raw data underpinning the authorization of NK603 in Europe are also made public. And he wants all the data to be assessed by an independent international committee, arguing that experts involved in the authorization of the maize should not be involved. EFSA chief Catherine Geslain-Lanéelle dis­agreed, and said that her agency is well placed to assemble a multi­disciplinary group to give an impartial assessment.

Some scientists, however, have long questioned whether such feeding studies are appropriate for testing the safety of whole foods, says Peter Kearns, head of food safety, nanosafety and chemical accidents for the Organisation for Economic Co-operation and Development in Paris. They were designed for testing chemicals where precise doses of purified and well-characterized compounds can be administered, whereas compounds in foods are heterogeneous, and doses are difficult to control. Regulators rely mainly on more robust tests that compare the toxicological and nutritional profiles of GM foods with their non-GM counterparts to screen for potential concerns.

Nature
October 16, 2012

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Meeting pigs’ phosphorous requirements with fermented soybean meal

Fermented soybean meal (FSBM), considered a promising substitute for fish meal in weanling pig diets because of its protein content, lower cost, and lack of anti-nutritional factors, may have an additional advantage. University of Illinois researchers recently found that pigs digest the phosphorus in FSBM better than the phosphorus in conventional soybean meal. Most of the P in soybean meal is bound to phytate, so it’s not available to pigs,” explained animal sciences professor Hans Stein. Previous research by Stein’s group found that pigs digest the phosphorus in fermented corn more easily than that in non-fermented corn. “Fermentation releases phosphorus from the phytate molecule,” Stein said. In this study, Stein and his team looked at whether FSBM offered the same advantage. They observed that the standardized, total-tract digestibility of phosphorus in FSBM is 65.5 percent, compared with 46.1 percent in conventional soybean meal. When the enzyme phytase was added to the diets, the digestibility of phosphorus in FSBM increased slightly to 71.9 percent, whereas phosphorus digestibility in conventional soybean meal increased to 71.4 percent.

“In conventional soybean meal, the majority of the phosphorus was bound in phytate, but the phytase enzyme released much of the phytate-bound phosphorus,” Stein explained. “That is why the digestibility increased so much when we added phytase to conventional soybean meal. In FSBM, fermentation had already released much of the phosphorus from phytate, so adding phytase did not improve digestibility very much.” These results show that fermentation is almost as effective as the enzyme phytase at releasing phosphorus. Producers can save money on phosphorus by using fermented soybean meal. “If swine producers use fermented soybean meal without phytase, they can use a greater digestibility value for phosphorus than if they use conventional soybean meal. Therefore, they need less supplemental phosphorus from other sources in the diets to meet the pig’s requirements,” Stein said. The study was published in a recent issue of the Journal of Animal Science and was co-authored with doctoral candidate Oscar Rojas.

Science Daily
October 16, 2012

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Hungry monkeys not living longer

Slash your food intake and you can live dramatically longer—at least if you’re a mouse or a nematode. But a major study designed to determine whether this regimen, known as caloric restriction, works in primates suggests that it improves monkeys’ health but doesn’t extend their lives. That outcome contradicts a similar study of monkeys reported 3 years ago. Researchers not involved with the new paper say the results are still encouraging. Although the monkeys didn’t evince an increase in life span, “both studies show a major improvement in ‘health span,'” or the amount of time before age-related diseases set in, says physiologist Eric Ravussin of the Pennington Biomedical Research Center in Baton Rouge. “I certainly wouldn’t give up on calorie restriction as a health promoter” based on these findings, adds molecular biologist Leonard Guarente of the Massachusetts Institute of Technology in Cambridge. For many species, eating between 10% and 40% less than normal not only prolongs life, but also improves metabolic measures such as insulin sensitivity and defers age-related ailments such as cancer and heart disease. Scientists haven’t nailed down what happens to humans on this extreme diet. The first randomized study, the 2-year CALERIE trial, wrapped up earlier this year. Ravussin, who is one of the trial’s leaders, says that the final results haven’t been analyzed, but in 2011, he and a colleague revealed that 6 months of calorie cutting reduced the participants’ risk of cardiovascular disease by 28%.

Testing whether calorie restriction also stretches human life span is impractical, however, so more than 20 years ago, scientists put two groups of rhesus monkeys (which have an average life span of about 27 years) on skimpy rations. In 2009, researchers reported in Science that a group of monkeys at the Wisconsin National Primate Research Center in Madison was reaping the benefits of the diet. Eating less cut rates of cancer and heart disease by half, for example. More than 50% of the animals were still alive, but the team detected a survival trend. Although overall mortality was the same, only 13% of the calorically restricted monkeys had died from age-related conditions, versus 37% of the control animals. Those findings jibe with most of the results from the second group of monkeys, which have been living and dying at the National Institutes of Health Animal Center in Dickerson, Maryland. “I think this report is quite positive,” says senior author Rafael de Cabo, a gerontologist at the National Institute on Aging in Baltimore, Maryland. For instance, the team found that none of the Maryland monkeys that started calorie restriction when they were young have developed cancer. De Cabo and colleagues reveal online today in Nature that dieting monkeys also showed lower blood levels of triglycerides, which influence the risk for cardiovascular disease. But a disparity between the groups emerged when the team analyzed longevity. About half of the animals are still alive, so the researchers don’t have definitive life span data. However, the famished monkeys don’t appear to be living longer than control monkeys that ate more.

One possible cause of the discrepancy, de Cabo says, is a difference in the animals’ diets. The Maryland monkeys noshed on more healthful food that included plenty of complex plant compounds, whereas the Wisconsin monkeys consumed processed food high in refined sugar. Control animals in Wisconsin also ate more than control animals in Maryland, which may even be slightly calorically restricted, de Cabo says. He notes that calorie restriction produces a bigger effect on longevity “if the control group is couch potatoes.” Genetic variability between the groups could also be a factor. The Maryland group was more diverse, including Indian and Chinese animals, whereas the Wisconsin monkeys all came from India. Studies of other organisms have shown that genetic differences between individuals can affect the response to calorie restriction, notes molecular biologist Matt Kaeberlein of the University of Washington, Seattle, who wasn’t involved with the research. For now, gerontologist Richard Weindruch, who heads the Wisconsin monkey project, isn’t ready to give up on a longevity effect. He notes that some control and calorically restricted animals in the Maryland group surpassed by several years what researchers thought was the maximum life span for the species, about 40 years. That suggests the animals’ diets do increase how long they can live, he says.

ScienceNow
September 18, 2012

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Fish and rice flourish together in paddies

A traditional farming technique that cultivates rice and fish side-by-side could help small farmers earn more money from their crops and reduce the impact on the environment, according to a study. When fish were introduced into flooded paddy fields, farmers were able to grow the same amount of grain as in conventional rice monocultures — but with more than two-thirds less pesticide and a quarter less fertiliser, found a six-year long study conducted in China. These rice-fish co-cultures could lessen the environmental impact of agricultural chemicals and help make rice farming more profitable, said the study, published in the Proceedings of the National Academy of Science this week. Fish minimized the need for fertilizer. “In areas where land and water are limited for developing both rice and fish production, it is important to conduct RF rice-fish co-culture,” Xin Chen, lead author of the study and a professor at Zhejiang University, China, told SciDev.Net. She added that the technique should be combined with modern techniques such as irrigation, and the use of machinery. The fish used in the study were an indigenous carp species that is considered a delicacy, so farmers could sell them. They could also make large savings on fertilisers and pesticides, which typically represent 60–70 per cent of the total cost of rice production.

Nature
November 29, 2011

Original web page at Nature

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Feeding cows natural plant extracts can reduce dairy farm odors and feed costs

With citizens’ groups seeking government regulation of foul-smelling ammonia emissions from large dairy farms, scientists report that adding natural plant extracts to cow feed can reduce levels of the gas by one-third while reducing the need to fortify cow feed with expensive protein supplements. They reported in Denver at the 242nd National Meeting & Exposition of the American Chemical Society (ACS). J. Mark Powell, Ph.D., described the results of three studies undertaken to determine how adding plant substances called “tannins” to cow feed affects the emission of ammonia from dairy barn floors and farm fields fertilized with mixtures of cow manure and urine. “For dairy farms, cow urine is the source of the ammonia emission problem,” said Powell, who is with the U.S. Department of Agriculture (USDA) Agricultural Research Service (ARS). “Dairy cows excrete large amounts of urine, about 3.5 gallons daily for each cow. That’s almost 1,300 gallons per year. And there are about 10 million dairy cows in the United States alone. Cows usually are fed a high-protein diet, and they produce various nitrogen compounds when they digest protein. They release the excess nitrogen mainly in their urine, and enzymes convert it into ammonia.”

Ammonia has an acrid, eye-tearing odor and has potential adverse health effects on both cows and humans. Citizens’ groups several months ago petitioned the U.S. Environmental Protection Agency (EPA) to begin regulating ammonia under the Clean Air Act, intensifying the search for practical, inexpensive ways to reduce emissions of the noxious gas. Besides its pungent odor, ammonia adds to air pollution, forming particles that travel long distances and contribute to environmental issues such as smog, acid rain and nutrient pollution. The ammonia problem originates with the nitrogen-rich protein in cow feed. Cows’ digestive systems are inefficient, and barely one-third of the nitrogen in their feed ends up in milk. The rest exits in urine and feces. The nitrogen in urine is in the form of urea, and enzymes contained in cow manure on the barn floor quickly convert it into ammonia gas. Tannins apparently reduce urea production by allowing more protein to escape digestion in the stomach and enter the cow’s intestines, where it’s used to produce milk protein.

Powell began investigating tannins in animal feed 20 years ago in West African communities where he lived and worked. Tannin-rich shrubs were grown as windbreaks to reduce soil erosion and to feed livestock. Tannins also are a key part of the diets of cattle, sheep and goats in tropical areas where vegetation tends to be naturally higher in the astringent plant chemicals. However, tannins have attracted relatively little attention elsewhere, Powell said. He hopes the addition of tannins to animal feed will become much more widespread in light of the findings about their potential for curbing ammonia emissions. The tannin extracts used in the studies are already approved for animal feed and would cost only a few cents a day, he said. Tannins are perhaps best known for their use in tanning leather, and the quebracho and chestnut trees are sources for both leather tanning and cattle feed. Powell said that it may be possible to produce synthetic tannins at a lower cost. Next on Powell’s agenda is research to determine whether tannins also can reduce emissions of methane gas — a potent greenhouse gas involved in global warming — from cattle production. About 25 percent of methane emissions in the United States are from enteric fermentation (mostly belches) of domestic cattle.

Science Daily
September 20, 2011

Original web page at Science Daily

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Chillingham cattle cowed by climate change

The team of ecologists lead by Dr Sarah Burthe of the Centre for Ecology & Hydrology were able to use the cattle to discover more about the impact of climate change on phenology in mammals because – encouraged by Charles Darwin – information about the cattle has been collected since 1860. According to Dr Burthe: “Charles Darwin encouraged the owner to keep records of births, deaths and ‘notable occurrences’, but he couldn’t have anticipated that these records could contribute to our understanding of the biology of global climate change.” Long-term datasets are crucial tools for studying climate change, yet very few exist. “The Chillingham cattle data are unique and, as far as we know, the longest mammal phenology dataset in the world. It’s an amazing dataset,” she says. The Chillingham cattle are feral – previously domesticated but now kept wild and unmanaged – and have distinctive white coats, red ears and horns. As well as being monitored for decades, the Chillingham cattle differ from most other UK mammals because they give birth throughout the year, not only during spring and summer. Examining data for the past 60 years, they found the biggest change was the increasing number and proportion of Chillingham calves born during the winter. And when they compared winter births with UK Met Office weather data, they found warmer springs nine months earlier were responsible.

“Cattle have a nine-month gestation period. Warm springs allow vegetation to start growing earlier, providing the cattle with more nutritious plant growth, and more cows conceive earlier as a result,” Dr Burthe explains. More calves being born in the winter, however, is bad news for the herd, she says: “Winter-born calves don’t do very well and are more likely to die before they reach the age of one. This suggests that the cattle are responding to climate change but this is having a negative impact on them.” The results are important because they show that even species able to breed year-round, which might be expected to cope better with environmental change, are altering the timing of their breeding schedules and these changes are having negative consequences. The study also plugs a major gap in understanding about phenology and climate change in an important group of animals. “Feral animals are often important components of ecosystems and used as tools for managing habitat, but we know very little about how they might respond to climate change.” “Understanding the consequences of phenology change and how widespread these responses are, even in relatively flexible species such as cattle that are able to breed year-round, helps us to predict the potential magnitude of changes caused by a warming climate.”

PhysOrg.com
June 28, 2011

Original web page at PhysOrg.com

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Methane gas from cows: The proof is in the feces

Scientists could have a revolutionary new way of measuring how much of the potent greenhouse gas methane is produced by cows and other ruminants, thanks to a surprising discovery in their poo. Researchers from the University of Bristol and the Teagasc Animal and Grassland Research Centre in Ireland, have found a link between methane production and levels of a compound called archaeol in the feces of several fore-gut fermenting animals including cows, sheep and deer. The compound could potentially be developed as a biomarker to estimate the methane production from domestic and wild animals, allowing scientists to more accurately assess the contribution that ruminants make to global greenhouse gas emissions. Co-author Dr Fiona Gill, who conducted the work as a postdoctoral researcher at Bristol and is now at the University of Leeds, said: “When it comes to calculating carbon budgets there is currently a lot of uncertainty surrounding animal methane contributions, particularly from wild ruminants.

“We’re quite good at measuring man-made CO2 emissions, but techniques to measure the animal production of methane — a much more potent greenhouse gas — have serious limitations. “If we can identify a simple biomarker for methane production in animal stools, then we can use this along with information on diet and animal population numbers to estimate their total contribution to global methane levels.” Cows, sheep and other ruminants are thought to be responsible for around one-fifth of global methane production but the precise amount has proved difficult to quantify. Methane production from animals is often measured using respiration chambers, which can be laborious and are unsuitable for grazing animals. Archaeol is thought to come from organisms called archaea, which are symbiotic or ‘friendly’ microbes that live in the foregut of ruminant animals. These microbes produce methane as a by-product of their metabolism and this is then released by the animal as burping and flatulence.

Principal investigator, Dr Ian Bull of Bristol’s School of Chemistry said: “We initially detected archaeol in the feces of several foregut fermenters including camels, cows, giraffes, sheep and llamas. We then expanded the study to evaluate the quantities of this compound in the feces of cows with different diets. “Two groups of cows were fed on different diets and then their methane production and fecal archaeol concentration were measured. The animals that were allowed to graze on as much silage as they wanted emitted significantly more methane and produced feces with higher concentrations of archaeol than those given a fixed amount of silage, supplemented by concentrate feed. “This confirms that manipulating the diet of domestic livestock could also be an important way of controlling methane gas emissions.”

Science Daily
June 28, 2011

Original web page at Science Daily

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Gorillas go green: Apes shed pounds while doubling calories on leafy diet

In the U.S., even zoo gorillas need to switch to a heart-healthy diet. “A lot are dying of heart disease, we believe like humans,” said Elena Hoellein Less, a PhD candidate in biology at Case Western Reserve University. In fact, heart disease is the number one killer of male Western lowland gorillas — the only species of gorillas in North American zoos. After Brooks, a 21-year-old gorilla, died of heart failure at Cleveland Metroparks Zoo in 2005, Less and other researchers here took a hard look at how the animals’ lifestyle affects their health. Less now leads an effort to counter the killer disease by returning the primates to a diet more akin to what they’d eat in the wild. Gone is the bucketful of vitamin-rich, high-sugar and high-starch foods that zoos used for decades to ensure gorillas received enough nutrients. Instead, Cleveland’s Mokolo and Bebac receive a wheelbarrow of romaine lettuce, dandelion greens and endive they gently tear and bite, alfalfa hay they nimbly pick through, young tree branches they strip of succulent bark and leaves, green beans, a handful of flax seeds, and three Centrum Silver multivitamins tucked inside half a mashed banana.

Instead of spending about a quarter of their day eating the old diet, the pair now spends 50 to 60 percent of each day feeding and foraging, about the same amount of time wild gorillas forage. Although they take in twice as many calories on the new diet, after a year, the big boys of the primate house have dropped nearly 65 pounds each and weigh in the range of their wild relatives. “We’re beginning to understand we may have a lot of overweight gorillas,” said Kristen Lukas, an adjunct assistant professor of biology at Case Western Reserve and chair of the Gorilla Species Survival Plan® (SSP®) for the Association of Zoos and Aquariums. The organization serves 52 zoos in the U.S. and Canada in a coordinated effort to improve the health and survival of the nearly 350 gorillas in the population. “And, we’re just recognizing that surviving on a diet and being healthy on a diet are different,” said Lukas, who is also curator of Conservation and Science at Cleveland Metroparks Zoo. “We’ve raised our standards and are asking, are they in the best condition to not only survive but to thrive?” Less is one of five Case Western Reserve graduate students in the biology program who are involved in research linking behavior to the health of zoo animals, a unique program among U.S. zoos, Lukas said.

At the same time Less has been monitoring the diet and resulting habits of the gorillas, she’s been measuring the amount of fat on the backs of the apes and attempting to discern what benefits against heart disease they may be gaining with the new diet, using biomarkers of insulin resistance and inflammation as guides. She’s also creating a body mass index for the animals, similar to that used to gauge healthy weight and makeup in humans. Though these zoo gorillas now weigh about the same or sometimes more than their wild counterparts, “we believe those in the wild have more muscle,” Less said. If the continuing study finds that to be true, she said, “The next step is exercising gorillas in zoos.” In addition to dropping weight and becoming active feeders, the gorillas also dropped a habit seen only in zoo gorillas, a habit that literally turned patrons away. Whether to taste sugar again and again, or to take up time not spent foraging or because large amounts of sugar and starch didn’t sit well; on the old diet, the gorillas would repeatedly spit up and then eat what they’d just spit up. “That behavior has been completely eliminated with the new diet,” Less said. Colleagues at other Gorilla SSP® institutions have allowed versions of the new diet to be tested at zoos in Columbus, North Carolina, Toronto and Seattle. Results are expected later this year. Should the larger sample prove the diet provides health benefits, the Gorilla SSP® may endorse high-fiber foraging at zoos nationally and internationally, Lukas said.

Science Daily
March 8, 2011

Original web page at Science Daily

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Key nutrient found to prevent cataracts in salmon

The role of a key nutrient which prevents cataracts in salmon has been revealed by eye specialists at the University of East Anglia. Research published September 30 in the American Journal of Physiology — Regulatory, Integrative and Comparative Physiology shows how the nutrient histidine, when added to the diet of farmed salmon, stops cataracts (clouding of the lens in the eye) from forming. Following fears over BSE in the early 1990s, blood meal was removed from the diet of farmed salmon. This coincided with a large increase in the incidence of cataracts which cause economic losses and fish welfare problems. Lead author Dr Jeremy Rhodes, from the Norwich Eye Research group at UEA, said: “The international research team of which we are a part have identified a key nutrient (histidine) that is present in high quantities in blood meal but was deficient in the post 1990s diet. We also found that by adding histidine to the salmon’s diet, cataract could be prevented.

“During the life cycle of salmon the young salmon parr spend the early part of their life in fresh water before they enter the sea as salmon smolts where they grow to maturity before returning to fresh water to spawn. “In this paper, the latest of several from the project, we show that histidine has a protective role in the lenses of salmon enabling them to withstand the considerable environmental stresses that their life cycle demands. When histidine is deficient in the diet, these environmental stresses lead to the development of cataract.” Salmon farming is worth $11 billion worldwide and Norway is the largest producer with a 33 per cent share. Fish farming is Norway’s third largest exporter after oil and metals. A multi-centre collaboration between the research labs of the University of East Anglia’s Norwich Eye Research Group and the National Institute of Nutrition and Seafood Research (NIFES) in Norway and industrial partners Biomar Ltd (Scotland) and Marine Harvest (Norway) was set up in 2004 to investigate the cause of the cataract outbreaks in farmed salmon.

The Norwich Eye Research Group at UEA has been a key member of this team and in addition to their vital research into the mechanism of the cataract formation has hosted scientists from the NIFES labs in Norway and sent scientists to Norway to help with collection of samples and the development of new techniques. The work of this collaborative group has had a global impact on the salmon farming industry and the dietary histidine content of farmed salmon has been increased as a direct result of this work. A synthetic histidine compound has recently been approved for use within the EU and work from the group was quoted in the conclusions of the European Food Safety Authority.

Science Daily
October 12, 2010

Original web page at Science Daily

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Veterinarian says natural foods not always best for pets

While natural food is a rising trend among humans, pet owners should be careful before feeding similar types of food to their pets, according to a Kansas State University veterinarian. All too often pet owners assume that because certain foods, such as fruits and vegetables, are healthy for them, they are also healthy for their pets, said Susan Nelson, K-State assistant professor of clinical services. “Natural and veggie-based pet foods are based more on market demand from owners, not because they are necessarily better for the pet,” she said. Natural pet food isn’t necessarily unhealthy for pets, and there are good brands on the market. But cats and dogs have specific nutritional needs that some of these foods may not provide, Nelson said. For instance, a natural dog food may provide antioxidants through fruits and vegetables, but it may be deficient in other nutrients the dog needs. If pet owners opt for natural pet food, it’s important to make sure pets still receive a well-balanced diet, she said.

Before buying any pet food that is labeled natural, owners should make sure it comes from a reputable company. Nelson said the Association of American Feed Control Officials, or AAFCO, sets guidelines for the production, labeling and distribution of pet food and sets minimum standards for the nutritional adequacy of diets. To ensure that food contains the proper nutrients a pet needs, pet owners should only buy pet food that has at least one of the two AAFCO nutritional adequacy statements on its label, Nelson said. The association’s standards determine whether a pet food company’s product is complete and balanced for a specific life stage according to one of two criteria: the diet’s formula meets the minimum nutrient requirements established by the association or the diet has undergone association feeding trials. Feeding trials, while not perfect, generally give the best assessment on how well the food performs for a specific life stage, Nelson said. Owners should look closely at the feeding statement on the label, as some foods are intended for intermittent feeding or only for specific life stages, and they could be detrimental to a pet if fed long-term.

Nelson said it is important to differentiate between terms such as natural, organic and holistic. Organic and holistic currently have no specific definitions for pet foods under the Association of American Feed Control Officials guidelines. Organic is defined by the U.S. Department of Agriculture for human food, but the department has no definition of natural foods for humans. The feed control association defines natural products as those that don’t contain any chemically synthesized ingredients except vitamins or minerals. The labels for natural products containing any of these ingredients must state: “Natural with added vitamins, minerals and other trace nutrients.” Consumers should be wary of any pet food company that claims to have organic or holistic food because they don’t exist by the association’s definition, Nelson said. Consumers should also pay attention to food ingredients. For instance, cats and dogs should not eat onions or garlic. While flaxseed oil can provide fatty acids for dogs, cats can’t use it for this purpose. Any manufacturer that uses these ingredients should be avoided, Nelson said.

“Most reputable companies have a veterinary nutritionist on hand,” Nelson said. “These companies also conduct nutritional research and have their own internal quality control in place.” Because dry pet food needs preservatives, there is often debate about whether artificial or natural preservatives are better. Studies show that synthetic preservatives seem to work better and aren’t bad for pets at the levels contained in the food. However, market demand is for using vitamins E and C because they are natural preservatives. As with any pet diet, pet owners who opt for natural pet food should keep an eye on their pets to make sure the food is not negatively affecting them, Nelson said. “Assuming the diet you have chosen meets AAFCO minimum standards of nutritional adequacy, and if your pet looks healthy, has good coat quality, is in good body condition, has good fecal consistency and is able to do its job, the diet is probably adequate for him,” she said.

Science Daily
September 28, 2010

Original web page at Science Daily

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New insights could mean better fish feeds

A better understanding of what happens in a fish’s body when it eats could lead to the production of better fish feeds. Researchers at the University of Gothenburg, Sweden, are hoping to contribute to more energy-efficient aquaculture. In the long term, this could increase the supply of farmed fish and so provide more food for the Earth’s burgeoning population. Studies of fish by researcher Henrik Seth from the University of Gothenburg’s Department of Zoology have helped to increase our understanding of what happens in parts of the body after one of its most frequently recurring activities: eating. It has long been known that a number of changes take place in the body following food intake, including an increase in blood flow to the stomach and intestines. This happens in humans and other mammals as well as in fish. However, we still know relatively little about the signals that trigger these changes and how they are regulated. Both the volume and the chemical composition of food play a role in how the body reacts. “It’s not just blood flow that is affected by its chemical composition, but also energy consumption in the stomach and intestines, and these factors are believed to be interlinked,” says Seth.

If energy consumption in the stomach and intestines rises, an increased blood flow will be needed to supply the active tissue with oxygen and nutrients. “Increased blood flow is also important for carrying away absorbed nutrients so that they can be used to nourish different parts of the body and to build up and repair different tissues.” The results of Henrik Seth’s research also show that parts of a fish’s nervous system are involved in this regulation, and that a number of hormones (including cholecystokinin) can affect this regulation depending on the composition of the food. It is primarily here that an increased understanding of this field could make it possible to produce fish feeds in the future that require less energy to be broken down and absorbed. “It might then be possible to enhance the growth of farmed fish, which would greatly increase the efficiency of fish farming with less wastage of energy,” says Seth. “Using nutrients as efficiently as possible may prove increasingly important as the global population continues to swell.”

Science Daily
August 31, 2010

Original web page at Science Daily

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Cutting fat and calories can lower cancer risk in dogs and people

As many as 1 out of 3 cancer deaths in both humans and dogs could be prevented by reducing Omega-6 fatty acids and cutting calories, according to research presented at the 2010 Institute of Food Technologists (IFT) Annual Meeting & Food Expo®. Demian Dressler, DVM, known as the “dog cancer vet” because of his work in the study of canine cancer, recommends severely limiting snack foods for humans and dogs that contain ingredients rich in Omega-6, such as corn oil, vegetable oil and grain-fed red meat. Too much Omega-6 fatty acid can lead to inflammation, which creates an environment conducive to cancer in dogs and people, he said. In addition, Dressler said studies show obesity in both dogs and humans limits the production of adiponectin, a hormone that has been shown to inhibit cancer cell growth. He recommended reducing calories, particularly those from sugar, which has the additional danger of not only causing obesity, but also feeding cancer cells and encouraging their growth.

In comparing human and canine cancer, Dressler bases his research on evidence that dogs have similar cancers to humans, and veterinary oncology uses almost all the human cancer drugs to treat dogs. A dog’s compressed lifespan allows researchers to see effects of the drugs quickly and apply those findings to humans. The panel encouraged pet food manufacturers to consider the health implications of their products to maximize the animal’s health. Kelly S. Swanson, associate professor in the Department of Animal Sciences at the University of Illinois at Urbana-Champaign, suggested the ideal blend of fiber for dog food is about 75 to 80 percent insoluble and 20 to 25 percent soluble. In addition, adding quality prebiotics to pet foods can enhance their gut health, he said, although research still is needed to determine how much is appropriate for an individual breed.

Science Daily
August 3, 2010

Original web page at Science Daily

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Hops helps reduce ammonia produced by cattle

An Agricultural Research Service (ARS ) scientist may have found a way to cut the amount of ammonia produced by cattle. To do it, he’s using a key ingredient of the brewer’s art: hops. Cattle, deer, sheep, goats and other ruminant animals depend on a slew of naturally occurring bacteria to aid digestion of grass and other fibrous plants in the first of their four stomach chambers, known as the rumen. The problem, according to ARS microbiologist Michael Flythe, comes from one group of bacteria, known as hyper-ammonia-producing bacteria, or HABs. While other bacteria are helping their bovine hosts convert plant fibers to cud, HABs are breaking down amino acids, a chemical process that produces ammonia and robs the animals of the amino acids they need to build muscle tissue, according to Flythe, who works at the ARS Forage Animal Production Research Unit (FAPRU) in Lexington, Ky.

To make up for lost amino acids, cattle growers have to add expensive and inefficient high-protein supplements to their animals’ feed. According to Flythe, hops can reduce HAB populations. Hops, a natural preservative, were originally added to beer to limit bacterial growth. Flythe put either dried hops flowers or hops extracts in either cultures of pure HAB or a bacterial mix collected from a live cow’s rumen. Both the hops flowers and the extracts inhibited HAB growth and ammonia production. Flythe and FAPRU plant physiologist Isabelle Kagan have completed a similar project with more typical forage. They recently identified a compound in red clover that inhibits HAB. Results of that study were published recently in Current Microbiology. Flythe also collaborated with FAPRU animal scientist Glen Aiken on a study in which hops had a positive effect on the rumen’s volatile fatty acid ratios, which are important to ruminant nutrition.

Science Daily
August 3, 2010

Original web page at Science Daily

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Animal feed, not automobiles, makes the San Joaquin Valley a smog hotspot

A new study identifies cattle feed as a possible culprit in the long-standing mystery of why California’s San Joaquin Valley — a moderately-populated agricultural region — has higher levels of ozone (one of the main ingredients in smog) than many densely-populated cities. The report, which explains how fermented cattle feed works with automotive exhausts in forming ozone, is in ACS’ Environmental Science & Technology. Michael Kleeman and colleagues note that high ozone levels in the San Joaquin Valley, which produces 10 percent of America’s food, have puzzled scientists for years. Motor vehicles are the major source of smog elsewhere, but the Valley has fewer motor vehicles compared to big urban areas with similar levels of ozone. Suspicion thus fell on farming activities, and the new study investigated the role of fermented livestock feed. The paper documents emissions of reactive organic gases, which react with combustion emissions and sunlight to form smog, from seven different animal feeds. It shows how fermented feed like silage appears to be the largest man-made source of these organic gases that contribute to ozone formation in the Valley even more than automobiles. The until-now-unrecognized animal-feed factor may account for the failure of traditional vehicle smog control regulations in the Valley, they note.

Science Daily
May 11, 2010

Original web page at Science Daily

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Scientists discover influenza’s Achilles heel: Antioxidants

As the nation copes with a shortage of vaccines for H1N1 influenza, a team of Alabama researchers have raised hopes that they have found an Achilles’ heel for all strains of the flu — antioxidants. In an article appearing in the November 2009 print issue of the FASEB Journal, they show that antioxidants — the same substances found in plant-based foods — might hold the key in preventing the flu virus from wreaking havoc on our lungs. “The recent outbreak of H1N1 influenza and the rapid spread of this strain across the world highlights the need to better understand how this virus damages the lungs and to find new treatments,” said Sadis Matalon, co-author of the study. “Additionally, our research shows that antioxidants may prove beneficial in the treatment of flu.” Matalon and colleagues showed that the flu virus damages our lungs through its “M2 protein,” which attacks the cells that line the inner surfaces of our lungs (epithelial cells). Specifically, the M2 protein disrupts lung epithelial cells’ ability to remove liquid from inside of our lungs, setting the stage for pneumonia and other lung problems. The researchers made this discovery by conducting three sets of experiments using the M2 protein and the lung protein they damage.

First, frog eggs were injected with the lung protein alone to measure its function. Second, researchers injected frog eggs with both the M2 protein and the lung protein and found that the function of the lung protein was significantly decreased. Using molecular biology techniques, scientists isolated the segment of the M2 protein responsible for the damage to the lung protein. Then they demonstrated that without this segment, the protein was unable to cause damage. Third, the full M2 protein (with the “offending” segment intact) and the lung protein were then re-injected into the frog eggs along with drugs known to remove oxidants. This too prevented the M2 protein from causing damage to the lung protein. These experiments were repeated using cells from human lungs with exactly the same results. “Although vaccines will remain the first line of intervention against the flu for a long time to come, this study opens the door for entirely new treatments geared toward stopping the virus after you’re sick,” said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal, “and as Thanksgiving approaches, this discovery is another reason to drink red wine to your health.”

Science Daily
November 17, 2009

Original web page at Science Daily

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Owners should count calories for obese pets, consider several factors for good health

You might watch your daily calorie intake or glance over nutritional information on food packages, but do you do the same for your pet? Dr. Susan Nelson, a veterinarian and assistant professor of clinical sciences at Kansas State University, said there are several guidelines to follow when feeding your pet to ensure that it maintains good health. Just like human food packages, many cat and dog food packages contain nutritional information, Nelson said. Packages often list the kilocalories, protein, fat, carbohydrates and fiber per cup. In recent years, manufacturers started listing some nutritional information, including calorie content, for dog and cat treats. “In the past, we didn’t know how many calories were in various treats,” Nelson said. “Now that’s becoming more available, and that’s because more pets are becoming obese and their owners are asking for that information. Pets are overeating and underexercising, and they’re eating too many high-fat foods and treats.”

Nelson said these plumper pets do not only benefit from improvements in pet food quality, but also from the increased calorie content caused by the higher fat content of many premium diets. But does that call for owners to start counting calories for their pets? “It’s important to count calories if the pet is overweight, but it’s probably not necessary if you have a pet that is of normal weight,” Nelson said. “If it starts to get pudgy, you need to take a look at how much exercise it is getting, how much food you are feeding it, and how many treats you’re giving it.” Calories from treats should be no more than 10 percent of your pet’s diet. If owners want to count their pet’s calories, Nelson said, veterinarians can make diet calculations for dogs and cats. The overall recommendation for the amount of food to feed your pet is based on several factors, including the type of food you are feeding your pet, your pet’s metabolism and how much exercise it gets. “Generally, I tell people that unless your pet is overweight, go with the guidelines on the food bag,” she said. “If the pet is a little overweight, you should feed it for its ideal weight and not for its current weight.”

Nelson said if you want to compare different pet food brands’ nutritional information, you have to look at the nutritional content calculations based on the dry matter content. Often, this is not listed on the bag, so you might have to look online or call the company to find the information. “What most bags list is the nutritional analysis that is formulated on an as-fed basis,” she said. “To truly compare the nutrient content of foods, you have to look at the dry matter basis, which takes out water content.” Nelson said it’s typically best to start by following the feeding guidelines on the bag. She said people shouldn’t assume that feeding one cup of one diet is the same as feeding one cup of another, because pet foods can vary greatly in calories. She also suggests using a standard 8-ounce measuring cup for dry food. To determine if a pet is too heavy or light, Nelson said owners should look at several factors. You should not be able to see the animal’s ribs, but you should be able to feel them easily with a thin layer of fat over them. When you look at the animal from the side, its tummy should tuck up at the flank area and not hang in a straight line. If you look over the top of a dog, you should see an hourglass shape where it’s broad at the shoulders, narrow at the waist and broader at the hips. If the dog starts to thicken out, you should cut back on its calories and/or have it exercise more. “In general, make sure you’re feeding the appropriate diet for the life stage of your pet,” Nelson said. “If your pet is pregnant, a puppy or kitten, has special health condition needs or is a senior, there are foods formulated that best meet the nutritional demands for that condition.”

There are breeds of dogs and cats that have high metabolisms and have trouble putting weight on, Nelson said. For these pets, there are pet foods that have higher fat contents because it gives the food more calories. If the pet is extremely overweight, it might need diet food along with other recommendations. These foods are lower in calories, nutritionally complete and often contain extra fiber, which helps make the animal feel full. Conversely, if you feed the animal much less of their regular food, your pet is not going to get enough of the nutrients it needs. Nelson said many people do not realize how many calories they’re feeding their pet because they don’t account for table scraps or treats. These hidden calories can add up significantly over the day and be the main contributor to obesity. Putting your pet on a diet requires attention and effort from the whole family, she said. If you have a small child, inside pets are going to eat everything the child drops, and those calories will add up. “Sometimes you’ll try to put your pet on a diet, and then someone else living in the house will slip it treats,” Nelson said. “You should talk with the whole family when putting your pet on a diet. Tell them the diet is necessary to keep the pet at a good weight, which in turn will make it healthier and can help it live a longer life.”

Science Daily
October 20, 2009

Original web page at Science Daily

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Secret of Scotland’s shrinking sheep solved

Call it the case of the shrinking sheep. On the remote Scottish island of Hirta, sheep have been getting smaller, shrinking an average of 5% over the last 24 years. Don’t blame evolution, though. Researchers say climate change is the real culprit. The Hirta sheep belong to a breed known as Soay, after the remote Scottish island where they arose. One of the most primitive forms of domestic sheep, Soays first came to Hirta in 1932. Because Hirta is a remote island, its sheep have remained genetically isolated, and no other sheep have been brought in for breeding. That’s made Hirta’s Soays ideal subjects for scientific study. In 2007, scientists first reported that the sheep were smaller than they had been in the past. This prompted biologist Arpat Ozgul of Imperial College London and colleagues to analyze body weight data going back 24 years. The researchers confirmed that the Soays had indeed been getting smaller. And, as they report online today in Science, the reason appears to be climate change.

In the past, Hirta’s sheep gorged on grass during their first summer, the team notes, piling on the weight in order to make it through the island’s typically harsh winters. But over the past quarter-century, Hirta has had unusually short and mild winters. As a result, Ozgul and colleagues propose, grass has become available for more months of the year, meaning the Soay sheep do not have to bulk up as much. In addition, Hirta’s harsh winters used to kill small ewes born to young mothers. But now these small ewes survive–and because of their low birth weight, they never get as big as normal sheep. That drives down the average size of the entire population, the team reports. Further mathematical modeling allowed the researchers to propose that natural selection has played little–if any–role in the shrinkage of the Hirta sheep. Malcolm Gordon, an ecologist and evolutionary biologist at the University of California, Los Angeles, praises the study. But he says that other mechanisms may be at work. “Changing environmental conditions on the island … may have led to changes in the chemical composition and nutritional value of the plant foods the sheep eat,” he says, and that may have shrunk the sheep. Though at the end of the day, he says, climate change could still be the root cause.

ScienceNow
July 28, 2009

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Way to cut cattle methane, threat to environment, by 25 percent

Beef farmers can breathe easier thanks to University of Alberta researchers who have developed a formula to reduce methane gas in cattle. By developing equations that balance starch, sugar, cellulose, ash, fat and other elements of feed, a Canada-wide team of scientists has given beef producers the tools to lessen the methane gas their cattle produce by as much as 25 per cent. “That’s good news for the environment,” said Stephen Moore, a professor of agricultural, food and nutritional science at the University of Alberta in Canada. “Methane is a greenhouse gas, and in Canada, cattle account for 72 per cent of the total emissions. By identifying factors such as diet or genetics that can reduce emissions, we hope to give beef farmers a way to lessen the environmental footprint of their cattle production and methane reductions in the order of 25 per cent are certainly achievable.” Using information from previous studies, the researchers compiled an extensive database of methane production values measured on cattle and were able to formulate equations to predict how much methane a cow would produce based on diet.

Science Daily
May 19, 2009

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Fresh fruits and vegetables are increasingly recognized as a source of food poisoning outbreaks

Raw fruits and vegetables are good for you but may also send you to the doctor, according to research published today by Cambridge University Press in the journal Epidemiology and Infection. A review article in the journal, written by several experts in their field, has highlighted the fact that fresh fruits and vegetables are increasingly recognised as a source of food poisoning outbreaks in many parts of the world. In Europe, recent outbreaks have revealed new and unexplained links between some bacterias and viruses that cause food poisoning and imported baby corn, lettuces, and even raspberries. In the USA, recent outbreaks of E Coli infections have been linked to bagged baby spinach, and Salmonella to peppers, imported cantaloupe melons and tomatoes as well. Professor Norman Noah, Editor-in-Chief of the journal says: “This research confirms that raw fruit and vegetables can cause food poisoning. To obtain raw fruit and vegetables out of season, as many countries now do, they are transported many thousands of miles from growing areas, and outbreaks can affect many widely dispersed countries simultaneously. Some outbreaks undoubtedly go unrecognized, and the scale of the problem is as yet unknown.

“Identifying the source of contamination in any outbreak requires a careful assessment of potential exposures. Further work needs to be done to fully understand fully where the organisms that causes the poisoning comes from, and at which point in the journey from field to fork.” In the journal, the links between raw produce and food poisoning have been compared with other foods that are now well-recognized sources of infection with particular bacteria, such as eggs with salmonella and beef mince with E Coli.

Science Daily
March 10, 2009

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Intestinal health in salmon fed a plant-based diet

Access to marine raw materials for fish feed production is limited. Any future increase in the numbers of farmed salmon will therefore necessitate an increased use of feeds of plant origin. If salmon are to grow satisfactorily and remain healthy, it is important to obtain knowledge of just how plant-based feed affects the health of fish. For his doctorate, Einar Lilleeng studied how plant ingredients in fish feeds affect the health and immune defence of fish. It is important to gain more knowledge of this field so that we can develop feeds rich in plants that are not detrimental to fish health. Lilleeng’s work has increased our understanding of how plant-rich feedstuffs, which contain a series of anti-nutrients, affect the digestive processes and immune system of the salmon intestine. Simultaneously, the research has contributed to a basic understanding of how fish digestive and immune systems function. Lilleeng utilised soya for his plant ingredient and used molecular-biological methods to study what happens in the fish intestine. The research comprised a series of feeding trials with salmon, of both short and long durations, so that both acute and more chronic reactions in the intestine could be studied.

As mentioned above, any increase in the Norwegian production of salmon will necessitate an increased use of plant-based feeds. Replacing marine ingredients with plant-based ingredients exposes fish to a series of “foreign” components, for example, starch and anti-nutrients that may upset natural processes occurring in the intestine. Plant components such as lectins, saponins, phyto-oestrogens, phytic acid, tannins and others, which do not exist in the natural feed of wild fish, may disturb digestive processes and affect health. Plant ingredients also introduce proteins that may stress the immune system of the intestine. Lilleeng used soya meal as the source of his ingredients, which is known to contain a series of anti-nutrients and to disturb the intestinal function of salmon. Lilleeng showed that intestinal immune defences become activated immediately feeding with soya commences. He also showed that enzymes normally associated with protein digestion have abnormally high levels of activity in the intestines of salmon with enteritis as a result of soya feeding. It appears that the intestinal mucous membrane, which previously has not been considered to be a source of these enzymes, also contributes to the high levels.

Lilleeng and his colleagues have increased our knowledge of the receptors of the fish intestine, so-called PAR2-receptors, which may be activated by such digestive enzymes. Activation of these receptors is very likely a key factor in the development of soya-induced enteritis. This work has been an important contribution to the understanding of how the fish intestine defends itself against harmful substances in the feed and against disease generally. The use of plant ingredients in the feed may expose the salmon to too much starch. The nutritive value of starch is limited, since salmon digest starch very poorly. By cloning and studying amylase, the enzyme that digests starch, Lilleeng and his colleagues have shown that the enzyme is missing an important part, a kind of “hook” that binds the starch so the enzyme can digest it. They also showed that a molecule that is important for the secretion of the enzyme into the intestine differs in salmon and mammals. this may explain why there is little amylase to be found in the fish intestine. These characteristics of salmon amylase may explain why salmon digest starch so poorly.

Science Daily
January 13, 2009

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Baby formula contamination may be linked to pet food contamination

A new study describes the kidney toxicity of melamine and cyanuric acid based on research that was done to characterize the toxicity of the compounds that contaminated pet food in North America in 2007. This research points to a possible link between the pet food contamination that occurred in North America in 2007 and the recent adulteration of milk protein and resultant intoxication of thousands of babies from Asia. The research described in the paper identifies the principal contaminants as melamine and cyanuric acid. Neither of these compounds is very toxic when administered alone; however, when given in combination, the two compounds form a virtually insoluble complex. This complex forms in the tubules of the kidney, blocking urine flow and causing renal failure. The research in the paper was done in rats, but because the toxicity depends only on the two compounds being present in the kidney at the same time, is relevant to other species, including humans. The research presented in the paper also shows that the melamine-cyanuric acid complex is soluble in acid, suggesting that acidification of the urine in the distal tubules of the kidney may be a reasonable treatment option.

Science Daily
October 28, 2008

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Genetically modified root systems result in plants that survive with little water

A part of the global food crisis is the inefficiency of current irrigation methods. More irrigated water evaporates than reaches the roots of crops, amounting to an enormous waste of water and energy. Tel Aviv University researchers, however, are investigating a new solution that turns the problem upside-down, getting to the root of the issue. They are genetically modifying plants’ root systems to improve their ability to find the water essential to their survival. When it comes to water, every drop counts. “Improving water uptake by irrigated crops is very important,” says Prof. Amram Eshel, the study’s co-researcher from Tel Aviv University’s Plant Sciences Department. His team, with that of Prof. Hillel Fromm, hope to engineer a plant that takes advantage of a newly discovered gene that controls hydrotropism, a plant’s ability to send its roots towards water.

Scientists in TAU’s lab are observing plants that are grown on moist air in the University’s lab, making it possible to investigate how the modified plant roots orient themselves towards water. Until now, aeroponics (a method of growing plants in air and mist) was a benchtop technique used only in small-scale applications. The current research is being done on the experimental model plant Arabidopsis, a small flowering plant related to cabbage and mustard. “Our aim is to save water,” explains Prof. Eshel. “We are increasing a plant’s efficiency for water uptake. Plants that can sense water in a better fashion will be higher in economic value in the future.” There can be significant water-saving consequences for farmers around the world. “We are developing plants that are more efficient in sensing water,” says research doctoral student Tal Sherman, who is working under Prof. Amram Eshel and Prof. Hillel Fromm.

Science Daily
August 19, 2008

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‘Burpless’ grass cuts methane gas from cattle

Genomics, are developing a grass that will not only cut the amount of methane cows burp up when chewing the cud but also grow in hotter climes. This means that farmers should be able to maintain dairy herds’ productivity and profitability in the face of a changing climate, while cutting down their gaseous burps and reducing their contribution to global warming. Combating greenhouse gas emissions produced by the agricultural industry is a priority. The UK’s DEFRA has just announced a roadmap aimed at helping the dairy industry reduce its potential impact on the environment in line with Britain’s target to cut its greenhouse emissions by 20% by 2010. By 2015 the roadmap plans to have 20-30% of milk producers trialling new technology to cut greenhouse gas emissions. The Inter-governmental Panel on Climate Change (IPCC) calculates that methane makes up 14.3% of humanity’s contribution to global warming and data from the National Oceanographic and Atmospheric Administration (NOAA) in the US shows that atmospheric methane levels may be rising again after a 10 year period of stability. A single dairy cow can produce between 550-700L of methane a day and it has been estimated that methane from cattle in the UK could account for as much as 3% of the country’s total greenhouse gas emissions.

Cows’ production of methane is down to the microflora in their gut that helps them to digest their food. As these microbes break down the grass’ cellulose, methane is produced as a by-product, the majority of which is burped up. David Beever, international nutrition director of Richard Keenan UK, said: ‘You don’t actually hear the cows burp, but they are permanently releasing methane.’ Gramina will use sense suppression technology to prevent the expression of the enzyme O-methyl transferase. Suppressing this enzyme leads to an increase in the digestibility of the grass without compromising its structural properties and therefore less burps and less methane. Gramina has already tested this modification in temperate grasses in the lab and glasshouses and is now planning field trials.

Science Daily
May 27, 2008

Original web page at Science Daily